Male depression may lower pregnancy chances among infertile couples, NIH study suggests


Among couples being treated for infertility, depression within the male partner was coupled to lower pregnancy chances, whereas depression in the female partner wasn’t found to influence the speed of live birth, according to a study funded by the National Institutes of Health.

The study, which appears in Fertility and Sterility, conjointly coupled a class of antidepressants known as non-selective serotonin reuptake inhibitors (non-SSRIs) to a higher risk of early pregnancy loss among females being treated for infertility. SSRIs, another category of antidepressants, weren’t coupled to pregnancy loss. Neither depression in the female partner nor use of the other class of antidepressant were coupled to lower pregnancy rates.

“Our study provides infertility patients and their physicians with new info to consider when making treatment decisions,” aforementioned study author Esther Eisenberg, M.D., of the Fertility and infertility Branch at NIH’s Eunice Kennedy Shriver National Institute of child Health and Human Development (NICHD), which funded the study.

Citing previous studies, the authors noted that 41 percent of women seeking fertility treatments have symptoms of depression. additionally, a study of men seeking IVF treatments found that nearly 50 percent experienced depression. The authors conducted this study to guage the potential influence of depression in couples seeking non-IVF treatments.

The researchers combined information from 2 previous studies funded by NICHD’s reproductive medication Network. One study compared the effectiveness of 2 ovulation-inducing drugs for institution of pregnancy and live birth in women with polycystic ovary syndrome. the opposite study compared the effectiveness of 3 ovulation-inducing drugs at achieving pregnancy and birth in couples with unexplained infertility. In every study, men and women responded to a questionnaire designed to screen for depression. only the women were asked whether they were taking any antidepressants.

From the 2 studies, the researchers analyzed data for 1,650 women and 1,608 men. Among the women, 5.96 percent were rated as having active major depression, compared to 2.28 percent of the boys.

Women using non-SSRIs were roughly three.5 times as probably to own a first trimester pregnancy loss, compared to those not victimisation antidepressants. Couples during which the male partner had major depression were 60 percent less likely to conceive and have a birth than those during which the male partner did not have major depression.

The study did not include couples who underwent in vitro fertilization because the authors thought that this procedure might doubtless overcome some possible effects of depression, like reduced sexual desire and lower sperm quality


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